Les activités de recherche du laboratoire de pharmacologie analytique du Pr Francis Beaudry concernent les axes suivants  :

1. Neurochimie de la douleur et de la nociception à l'aide d'organismes modèles (ex. C. elegans) etde la spectrométrie de masse.
2. Découverte de nouvelles cibles thérapeutiques.
3. Développement de nouvelles stratégies thérapeutiques pour le traitement de la douleur et de la maladie de Parkinson.
4. Étude de la pharmacocinétique et le métabolisme de médicaments utilisés pour le traitement de la douleur et de la maladie de Parkinson.

LePr Francis Beaudry a obtenu un baccalauréat en chimie (Université de Sherbrooke) et un doctorat en chimie médicinale (Anglia Ruskin University). Il a poursuivi ses travaux de recherche sur le traitement pharmacologique de la douleur dans le laboratoire du Pr Pascal Vachon. Le Pr Beaudry est entré en fonction le 1er juin 2009 à titre de professeur adjoint au département de biomédecine vétérinaire de l'Université de Montréal, promu au rang de professeur agrégé le 1er juin 2014 et au rang de professeur titulaire le 1er juin 2020. Le Pr Beaudry a acquis une vaste expérience dans le domaine de la chimie médicinale, de la spectrométrie de masse et de la bioanalyse. Le Pr Beaudry est l'auteur ou le coauteur de 156 publications dans des journaux scientifiques à comité de lecture et de 134 affiches présentées lors de congrès scientifiques nationaux et internationaux depuis le début de sa carrière scientifique.

• Membre de l'Ordre des chimistes du Québec

Publications (2020-2023)

G. Millette, E. Lacasse, R. Binette, V. Belley, L-P. Chaumont, C. Ster, F. Beaudry, K. Boyapelly, P-L. Boudreault, F. Malouin. Rationally Designed Pyrimidine Compounds: Promising Novel Antibiotics for the Treatment of Staphylococcus aureus-Associated Bovine Mastitis. Antibiotics. 12, 1344. https://doi.org/10.3390/ antibiotics12081344

H. Alarie, F. Beaudry, M. Houde and P.A. Segura (2023). Untargeted lipidomics to study sublethal effects of gemfibrozil on Daphnia magna. Environmental Science: Processes & Impacts. Manuscript ID: EM-ART-07-2023-000297. July 2023

C. Otis, E. Bouet, S. Keita-Alassane, M. Frezier, A. Delsart, M. Guillot, A. Bédard, J-P. Pelletier, J. Martel-Pelletier, B. Lussier, F. Beaudry and E. Troncy. Face and Predictive Validity of MI-RAT (Montreal Induction of Rat Arthritis Testing), a Surgical Model of Osteoarthritis Pain in Rodents Combined with Calibrated Exercise. International Journal of Molecular Sciences. 2023; 24(22):16341. https://doi.org/10.3390/ijms242216341

F. Boujenoui, J. Ben Salem, B. Nkambeu, J.D. Castano Uruena and F. Beaudry (2023). Cannabidiol and Tetrahydrocannabinol Antinociceptive Activity is Mediated by Distinct Receptors in Caenorhabditis elegans. Neurochemical Research. Manuscript ID: 5689be3f-bd89-4b89-9f7f-fa3213874e75. Accepted, In Press

J. Pujol, C. Vergneau-Grosset, F. Beaudry, F. Gaudette, A. Vigneault and I-C. Cruz Benedetti (2023). Pharmacokinetics and innocuity of a single dose of intravenous, intramuscular and subcutaneous methadone in domestic rabbit, Journal of Exotic Pet Medicine. 47, 41-46

M. Lahaise, F. Boujenoui and F. Beaudry (2023). Cannflavins Isolated from Cannabis sativa Impede Caenorhabditis elegans Response to Noxious Heat. Naunyn-Schmiedeberg's Archives of Pharmacology. https://doi.org/10.1007/s00210-023-02621-3

M. I. Atmane, A-L. Vigneau, F. Beaudry, C. Rico, D. Boerboom, M. Paquet (2023). Therapeutic trial of fluvastatin in a cell line xenograft model of canine mammary gland cancer. Veterinary and Comparative Oncology. 2023;21:634–645. https://doi.org/10.1111/vco.12926

W. Kang, S.G. Nuara, D. Bédard, I. Frouni, C. Kwan, A. Hamadjida, J.C. Gourdon, F. Gaudette, F. Beaudry and P. Huot (2023). The mGluR2/3 orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. Naunyn Schmiedebergs Arch Pharmacol. doi: 10.1007/s00210-023-02587-2

A. Zareifard, F. Beaudry, K. Ndiaye (2023). Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle- stimulating hormone (FSH) in bovine granulosa cells. BMC Molecular and Cell Biology 24 (1), 1-19

I. Frouni, D.Bédard, É. Bourgeois-Cayer, A. Hamadjida, F. Gaudette, F. Beaudry and P. Huot (2023). Pharmacokinetic profile of bitopertin, a selective GlyT1 inhibitor, in the rat. Naunyn-Schmiedeberg's Archives of Pharmacology. 396:1053–1060

W. Bo Sam Zhou, X. Qun Shi, Y. Liu, S. D. Tran, F. Beaudry and J. Zhang (2023). Unbiased proteomic analysis detects painful systemic inflammatory profile in the serum of nerve injured mice. Pain. 1;164(2):e77-e90.

M. Abdollahi, PA Segura and F. Beaudry (2023). Is non-targeted data acquisition for target analysis (nDATA) in mass spectrometry a forward-thinking analytical approach? Biomedical Chromatography. 37(7):e5531. doi: 10.1002/bmc.5531

B. Nkambeu, J. Ben Salem and F. Beaudry (2023). Antinociceptive Activity of Vanilloids in Caenorhabditis elegans is Mediated by the Desensitization of the TRPV Channel OCR-2 and Specific Signal Transduction Pathways. Neurochemical Research. 48(6): 1900-1911. https://doi.org/10.1007/s11064-023-03876-1

S. Mainguy-Seers, F. Beaudry, C. Fernandez Prada, J. G. Martin and J-P. Lavoie (2022). Neutrophilic extracellular vesicles and airway smooth muscle proliferation in the natural model of severe asthma in horses. Cells. 11(21):3347

P. Segura, C. Guillaumin, E. Eysseric, J. Boudrias, M. Moreau, C. Guérette, R. Clementin and F. Beaudry (2022). Ultra-fast analysis of peptides by laser diode thermal desorption-triple quadrupole mass spectrometry. Rapid Communications in Mass spectrometry. e9373. https://doi.org/10.1002/rcm.9373

A. Victoria Ibarra-Meneses, V. Wagner, A. Corbeil, F. Beaudry, R. L. do Monte-Neto and C. Fernandez-Prada (2022). Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach. Frontiers in Cellular and Infection Microbiology. 12:954144. doi: 10.3389/fcimb.2022.954144. 

J. Ben Salem, J. S. Iacovoni, D. Calise, D. N. Arvanitis, F. Beaudry (2022). Proteomics reveals long-term alterations in signaling and metabolic pathways following both myocardial infarction and chemically induced denervation. Neurochemical Research. 47(8):2416-2430 https://doi.org/10.1007/s11064-022-03636-7

S. Keita-Alassane, C. Otis, E. Bouet, M. Guillot, M. Frezier, A. Delsart, M. Moreau, A. Bédard, I. Gaumond, J-P Pelletier, J. Martel-Pelletier, F. Beaudry, B. Lussier, R. Lecomte, S. Marchand, E. Troncy (2022). Estrogenic impregnation alters pain expression: Analysis through functional neuropeptidomics in a surgical rat model of osteoarthritis. Naunyn-Schmiedeberg’s Archives of Pharmacology. 395(6):703-715 https://doi.org/10.1007/s00210-022-02231-5

 W. Kang, F. Gaudette, D. Bédard, F. Beaudry and P. Huot (2022). Quantitative determination of LY-404,039, a metabotropic glutamate 2/3 receptor agonist, in rat plasma by high performance liquid chromatography tandem mass spectrometry. Biomedical Chromatography. 9:e5423. Doi: 10.1002/bmc.5423

A.F. Salmin, M.J. Pesant, Y. Burgher, C. Provost, J. Labrie, M. Jacques, C. A. Gagnon and F. Beaudry (2022). Untargeted and targeted metabolomics reveal that adenosine nucleotides released in Actinobacillus pleuropneumoniae supernatant inhibit porcine reproductive and respiratory syndrome virus replication. Talanta. 242 :123315 https://doi.org/10.1016/j.talanta.2022.123315

S. Mainguy-Seers, R. Boivin, S. Pourali Dogaheh, F. Beaudry, P. Hélie, A. G. Bonilla, J. G. Martin, J- Lavoie (2022). Effects of azithromycin on bronchial remodeling in the natural model of severe neutrophilic asthma in horses. Scientific Reports, 12, Article number: 446 

J. Ben Salem, B. Nkambeu, D. Arvanitis and F. Beaudry (2022). Resiniferatoxin hampers the nocifensive response of Caenorhabditis elegans to noxious heat, and pathway analysis revealed that the Wnt signaling pathway is involved. Neurochemical Research. 47:622–633. https://doi.org/10.1007/s11064-021-03471-2

K. O’Dowd, L. Sánchez, J. Ben Salem, F. Beaudry and N. Barjesteh (2021). Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus. Membranes. 12, 53. https://doi.org/10.3390/ membranes12010053

F. Rousseau-Blass, A.E. Cribb, F. Beaudry, D.S. Pang. (2021). A Pharmacokinetic-Pharmacodynamic Study of Intravenous Midazolam and Flumazenil in Adult New Zealand White-Californian Rabbits (Oryctolagus cuniculus). Journal of the American Association for Laboratory Animal Science. 60(3): 319-328

E. Eysseric, F. Beaudry, C. Gagnon and P. Segura (2021). Non-targeted screening of trace organic contaminants in surface waters by a multi-tool approach based on combinatorial analysis of tandem mass spectra and open access databases. Talanta, 230: 122293. https://doi.org/10.1016/j.talanta.2021.122293

J. Raulic, F. Beaudry, G. Beauchamp, M. Jalenques, N. Summa, S. Lair, W. A. Youcef  and C. Vergneau-Grosset (2021), Pharmacokinetic, pharmacodynamic, and toxicology study of robenacoxib in rainbow trout (ensitizatio mykiss), Journal of Zoo and Wildlife Medicine, 52(2): 529–537

Y. Prud’homme, S. T. Ferrell, F. Beaudry, G. Beauchamp, S. Nichols, M. Desmarchelier (2021), Pharmacokinetics and clinical effects of a single oral dose of trazodone in the domestic goat (capra hircus) as a model for wild ruminants. Journal of Zoo and Wildlife Medicine, 51(4):896-904

C. Kwan, I. Frouni, S.G. Nuara, S. Belliveau, W. Kang, A. Hamadjida, D. Bédard, F. Beaudry, M. Panisset, J.C. Gourdon and P. Huot (2021). Combined 5-HT2A and mGlu2 modulation for the treatment of dyskinesia and psychosis in Parkinson’s disease. Neuropharmacology, 186:108465

M. Kermorgant, J. Ben Salem, J.S. Iacovoni, D. Calise, L. Dahan, B.P. Guiard, S. Lopez, O. Lairez, A. Lasbories, N. Nasr, A. Pavy Le-Traon, F. Beaudry, J.M. Senard, D.N. Arvanitis (2021). Cardiac sensory afferents modulate susceptibility to anxio-depressive behaviour in a mouse model of chronic heart failure. Acta Physiologica. 00:e13601

C. Kwan, S. G. Nuara, D. Bédard, F. Gaudette, J. C. Gourdon, F. Beaudry, P. Huot (2021). Selective blockade of the 5-HT3 receptor alleviates dyskinesia and psychosis in the parkinsonian marmoset. Neuropharmacology. 182:108386 

B. Nkambeu, J. Ben Salem and F. Beaudry (2021). Eugenol and Other Vanilloids Hamper Caenorhabditis elegans Response to Noxious Heat. Neurochemical Research. 46(2):252-264

F. Beaudry and P. Huot (2020). The MPTP-lesioned marmoset model of Parkinson’s disease: determining the minimal efficacy threshold required to predict successful clinical trials. Journal of Neural Transmission. 127(10):1343-1358

I. Frouni, F. Gaudette, D. Bédard, C. Kwan, A. Hamadjida, F. Beaudry and P. Huot (2020), Development and validation of a sensitive HPLC-HESI-MS/MS method for quantitative determination of bitopertin in rat and marmoset plasma following sub-cutaneous administration. MNI Open Research 2020, 4:2

P.V. Steagall, H. L. Marcelle Ruel, T. Yasuda, B. Paglerani Monteiro, R. Watanabe, M. Cayetano Evangelista and F. Beaudry (2020). Pharmacokinetics and analgesic effects of intravenous, intramuscular or subcutaneous buprenorphine (Simbadol) in dogs undergoing ovariohysterectomy: a randomized, prospective, masked, clinical trial. BMC Veterinary Research. 16:154. 

 B. Nkambeu, J. Ben Salem and F. Beaudry (2020). Capsaicin and its analogues impede nocifensive response of Caenorhabditis elegans to noxious heat. Neurochemical Research. 45(8): 1851-1859

J. Pelletier, J.-P. Rocheleau, C. Aenishaenslin, F. Beaudry, G. Dimitri, R. Lindsay, N. Ogden, C. Bouchard and P. Leighton (2020), Evaluation of fluralaner as an oral acaricide to reduce tick infestation in a wild rodent reservoir of Lyme disease. Parasites & Vectors. 13:73. 

 L. Sid-Otmane, A. Hamadjida, S.G. Nuara, D. Bédard, F. Gaudette, J.C. Gourdon, V. Michaud, F. Beaudry, M. Panisset and P. Huot (2020). Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset. European Journal of Pharmacology. 873:172957 

S. Leonelli, B. Nkambeu and F. Beaudry (2020). Impaired EAT-4 Vesicular Glutamate Transporter Leads to Defective Nocifensive Response of Caenorhabditis elegans to Noxious Heat. Neurochemical Research. 45(4):882-890.

C. Kwan, D. Bédard, I. Frouni, F. Gaudette, F. Beaudry, A. Hamadjida and P. Huot (2020). Pharmacokinetic profile of the selective 5-HT3receptor antagonist ondansetron in the rat: an original study and a mini-review of the literature. Canadian Journal of Physiology and Pharmacology. 98(7):431-440