Étude des mécanismes cellulaires et moléculaires impliqués dans la réponse immune innée et adaptative contre les polysaccharides capsulaires ou de surface de bactéries pathogènes extracellulaires. Plus précisément, la recherche vise à définir le rôle des cellules dendritiques (CDs) dans l’orchestration de ces réponses.
Laboratoire d'Immunologie, Faculté de médecine vétérinaire, Université de Montréal
Campus de Saint-Hyacinthe
Date limite : 15 août 2016
Dr. Mariela Segura
PhD, Immunologist Laboratory of Immunology
Faculty of Veterinary Medicine Université de Montréal
Dr. René Roy
PhD, Chemist
Director of PharmaQÀM Department of Chemistry Université de Québec à Montréal (UQAM)
The candidate will be involved in research projects of the Laboratory of Immunology (St-Hyacinthe campus) under the supervision of Dr. Mariela Segura and the co-supervision of Dr. René Roy.
Only candidates with Canadian citizenship or permanent Canadian residents or French citizenship will be considered. Under cooperation agreements between Quebec and France, French students are exempt and pay the same tuition fees as Québec students for graduate studies.
Deadline: 15 August 2016. However, late applications can be considered on a rolling basis. To submit your application: Please send your C.V., copies of grade transcripts, a presentation letter, and two references to the following address: mariela.segura@umontreal.ca
Project description: The student will be involved in aspects related to vaccine development and underlying immunological mechanisms. The proposed project focuses on the use of nanocarriers to improve antigen immunogenicity. Our model pathogen is Streptococcus suis, one of the most important bacterial pathogens in pigs and an emerging zoonotic agent of meningitis and septicemia. The applicant will perform in vitro, ex vivo and in vivo experiments after immunization using mouse models. Thus, he will need to learn and use different laboratory techniques such as: cell culture/purification, bacterial culture, ELISA, FACS, immuno-fluorescence, and mouse immunization. Several biochemistry techniques will be also required and will be performed under the supervision of Dr. Roy (UQAM). The project will thus provide a highly-competitive multidisciplinary training to the student.
Salary: Grants ranging from 16,000$ to 18,000$ will be offered to the applicant based on diplomas and past laboratory experience.
Requirements: MSc applicants need to possess a minimum of an undergraduate diploma and/or an equivalent, as per University of Montreal’s standards. All diplomas and/or equivalents must be in a specialized field such as: microbiology, immunology, biochemistry, or other related fields.
Research project is funded by: Canadian Glycomics Network (GlycoNet). Additional funding is provided by Natural Sciences and Engineering Research Council of Canada (NSERC), and Le Fonds de recherche du Québec – Nature et technologies (FRQNT).
Comment: Although the laboratory is located in a French environment, French language is not mandatory if the candidate is fluent in English.
Recent scientific publications related to research interests (selected list):
•Segura, M. Streptococcus suis vaccines: candidate antigens and progress. Expert Review of Vaccines. 14: 1587-608, 2015.
•Goyette-Desjardins, G., R. Roy, and M. Segura. Murine whole-blood opsonophagocytosis assay to evaluate protection by antibodies raised against encapsulated extracellular bacteria. In: Carbohydrate-Based Vaccines - Methods and Protocols Edition of "Methods in Molecular Biology" lab protocol series. B. Lepenies (Ed.) Springer, 2015.
•Calzas, C., P. Lemire, G. Auray, V. Gerdts, M. Gottschalk, and M. Segura. Antibody response specific to the capsular polysaccharide is impaired in Streptococcus suis serotype 2-infected animals. Infection and Immunity. 83: 441-453, 2015.
•Roy, R., and T.C. Shiao. Glyconanosynthons as powerful scaffolds and building blocks for the rapid construction of multifaceted, dense and chiral dendrimers. Chemical Society reviews. 44: 3924-41, 2015.
•Sharma, R., I. Zhang, L. Abbassi, R. Rej, D. Maysinger, and R. Roy. Fast track dendrimer synthesis using microwave assisted accelerated onion peel approach. Polym. Chem. 6: 1436-1444, 2015.
•Sharma, R., N. Kottari, Y.M. Chabre, L. Abbassi, T.C. Shiao, and R. Roy. A highly versatile convergent/divergent "onion peel" synthetic strategy toward potent multivalent glycodendrimers. Chemical communications. 50: 13300-3, 2014.
•Van Calsteren, M.R., F. Gagnon, C. Calzas, G. Goyette-Desjardins, M. Okura, D. Takamatsu, M. Gottschalk, and M. Segura. Structure determination of Streptococcus suis serotype 14 capsular polysaccharide. Biochemistry and Cell Biology. 91: 49-58, 2013.
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